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2em">文章的通訊作者是哈佛醫學院袁鈞英教授，袁鈞英教授是的華裔科學家。她一直從事細胞死亡的相關研究，2005年發現了一種細胞非調亡性的程序性死亡，英文稱為necroptosis，是之一。她還獲得了美國衛生研究所（NIH）頒發了的NIH主任獎（Directors Pioneer Award）。2000年起任哈佛大學醫學院終生教授，2004年被復旦大學國家重點實驗室管理委員會批準為遺傳工程國家重點實驗室海外客座教授。</div><div> </div><div style="text-indent: 2em">N-末端乙?；揎検窃谡婧松镏袕V泛存在的修飾形式，其中N末端α-乙?；∟-alpha-acetylation）通常是翻譯中同時發生的，一般發生在新生肽鏈大約40個殘基長的時候。這種修飾形式普遍存在，比如一些細菌細胞中大約80%的可溶蛋白是N端α-乙?；揎椀?。</div><div> </div><div style="text-indent: 2em">之前的研究證明N末端α-乙?；揎椀鞍着c細胞對凋亡信號的敏感性密切相關，在這篇文章中，研究人員通過生化實驗分析蛋白乙?；癄顟B，證明了蛋白N末端α-乙?；艿揭阴］o酶A（acetyl-CoA）的調控——乙酰輔酶A是乙?；幕罨问?，參與各種乙?；磻?，也是糖類、脂肪、氨基酸氧化時的重要中間產物。</div><div> </div><div style="text-indent: 2em">研究人員還提出，由于Bcl-xL是一種的影響線粒體代謝的抗凋亡蛋白，因此他們認為這一因子可能在末端α-乙?；揎椀鞍着c凋亡之間搭建了橋梁。研究人員通過一系列實驗證明了這一點，從而提出N末端α-乙?；揎椀鞍椎拇x調控可以促進細胞生存。</div><div> </div><div style="text-indent: 2em">袁鈞英教授研究組獲得了多項細胞凋亡的研究成果，去年還與國內的研究人員共同發現了一種新的具有葡萄糖濃度依賴的促胰島素分泌的小分子化合物，這不僅揭示了胰島素分泌調控的新機制，而且提出了一種可能作為新型促胰島素分泌劑的先導化合物。</div><div> </div><div style="text-indent: 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